Together, our results showed that JPX may regulate RABEP1 through miRNA (miR-145, miR-146ac, miR-216a, miR-216b, miR-24, miR-33ab, miR-129-5p), affecting CD8+ T cells, NK cells and eosinophils and other immune cells, and finally participating in the immune process of PAH. The gene discussed is CD8A; the disease is pulmonary arterial hypertension.