LGALS1 and neoplasm: Elevations in Gal-1 in the tumor microenvironment (TME) are well documented in various malignancies [27] and studies reveal key roles of Gal-1–glycosylated ligand interactions in promoting tumor migration and metastasis [28,29,30,31], vasculogenic mimicry [27,32,33], and immunomodulation [34].