In another study, the PI3K-AKT-β-catenin signaling pathway was suppressed in cancer colon cells due to Gal-1 retention at the plasma membrane via its interaction with the intracellular domain of Protocadherin-24 (PCDH24), a non-classical cadherin member that is downregulated in colorectal cancer [40]. This evidence concerns the gene LGALS1 and cancer.