Intactness of the plasma membrane in ONC201-treated cells, together with previous observations that ONC201 pretreated breast cancer cells are more susceptible to TRAIL and NK-cell mediated death [10], led us to further testing of the sensitivity of ONC210-treated cell toward TRAIL, a well-known inducer of inducers’ apoptotic cell death of cancer cells. Here, TNFSF10 is linked to breast cancer.