We analyzed the spatio-temporal expression pattern of FGFR1, FGFR2, and RIP5 in normal human kidney development and the development of CAKUT-affected kidneys from the 22nd to 41st developmental week (dw), to determine how they are related to the occurrence of CAKUT. Here, FGFR2 is linked to congenital anomaly of kidney and urinary tract.