The nuclear localization of FGFR1, elevated the expression score of FGFR1 mRNA, increased the area percentage of FGFR1-positive cells in the cortex of DYS kidneys, and the overall decrease in the expression after the peak at the 27th developmental week in DYS suggest the altered expression pattern and protein function is in response to CAKUT pathophysiology. This evidence concerns the gene FGFR1 and congenital anomaly of kidney and urinary tract.