Activating mutations of FGFR2 (or rarely FGFR1) can cause several syndromes: Apert, Pfeiffer, Antley–Bixler, or Beare–Stevens syndrome, which may be coupled with a phenotype belonging to the CAKUT spectrum: hydroureter, unilateral renal aplasia, or vesicoureteral reflux [16,17,18,19]. The gene discussed is FGFR1; the disease is congenital anomaly of kidney and urinary tract.