IL6 and cancer: Of note, both IL-6 and IL-8 can be released by tumor-associated macrophages [111], which are widely known to promote cancer progression and metastasis and, in turn, these cytokines could participate in the recruitment and expansion of MDSCs [112], which have been extensively associated with poor clinical outcomes in both HL and NHL due to their role in immune evasion and cancer progression through different mechanisms [113].