The recruitment of proinflammatory cytokines by leptin could regulate the production of adhesion molecules, such as the vascular cell adhesion molecule (VCAM)-1 and intercellular cell adhesion molecule (ICAM)-1 [159,160], that have been found to be highly increased in newly diagnosed lymphoma patients and correlate with tumor dissemination, the aggressiveness of the disease, and worse response to treatments [161,162,163,164]. This evidence concerns the gene LEP and lymphoma.