By contrast, it has also been shown that leptin levels not only undergo slight changes after treatment in NHL adult patients [168] but also could be negatively correlated with the international prognostic score in HL and with the international prognostic index in NHL [214], suggesting a paradoxical role of leptin that has been previously explained not only in cancer [40] but also in other settings [218,219,220]. This evidence concerns the gene LEP and Hodgkins lymphoma.