In line with this notion, leptin has been demonstrated to stimulate the proliferation of DLBCL cells and inhibit apoptosis via the PI3K/AKT signaling pathway in vitro, whereas the pretreatment of DLBCL cells with LEPR-specific siRNA or the inactivation of PI3K/AKT activity depleted these responses [200]. Here, AKT1 is linked to diffuse large B-cell lymphoma.