Inflammatory cytokines (IL-6 and TNF-α) levels were significantly (p < 0.05) increased in the colon tissue of DSS-induced colitis mice when compared with the control group, while LCS-SeNPs significantly reduced (p < 0.05) the levels of pro-inflammatory cytokines IL-6 and TNF (Figure 6A,B). This evidence concerns the gene IL6 and colitis.