Sarcolipin, an inhibitor of sarco/endo plasmic reticulum Ca2+-ATPase (SERCA), was significantly upregulated in different types of muscular dystrophies [22], including LMNA-related cardiomyopathy, while downregulation of sarcolipin led to delays in cardiac dysfunction in a mouse model [21]. This evidence concerns the gene SLN and cardiomyopathy.