Exceptionally in SOD1, V118L, and C146R-ALS cases, there is evidence of marked neuronal loss in dorsal vagal, solitary tract nuclei, and ambiguous nuclei [293,294], and in some cases, TDP-43 inclusions are present in the ambiguous nucleus which drives parasympathetic heart control [287]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.