More specifically, Feng et al. investigated the protein expression levels of p14ARF, p15INK4b, p16INK4a, p53, and Ki-67 in a tissue microarray of 20 samples of CIN (II-III) [187] and reported a significant upregulation of the senescence-associated markers p14ARF, p15INK4b, p16INK4a in CIN compared to their normal cervical epithelial counterparts, suggesting that cervical premalignant lesions are highly enriched in senescent cells [187]. This evidence concerns the gene TP53 and cervical squamous intraepithelial neoplasia.