Moreover, cancer-associated fibroblasts (CAF) were found to secrete high levels of IL-6 upon STAT3 activation and exhibit a senescence morphology in vitro or in cervical cancer tissues infected with high-risk HPV, where the overexpression of E6 activates STAT3, increases IL-6 expression and induces senescence [185]. Here, STAT3 is linked to cervical carcinoma.