Similar to how rheumatoid arthritis damages joints, miRNA-23a inhibits MMP-3, which results in the deterioration of several ECM components and, by inhibiting the production of RUNX2 and promoting the expression of lncRNA MT1DP that is mediated by YAP1, the same miRNA found in EVs could successfully decrease osteogenesis [96,97]. The gene discussed is RUNX2; the disease is rheumatoid arthritis.