miR-34 family miRNAs, such as miR-34a and -34c, are also shown to induce the release of pro-inflammatory cytokines and chemokines in the wound-edge epidermal keratinocytes of venous ulcers via targeting LGR4, thereby delaying the wound closure and contributing the pathological roles in venous ulcers [70]. This evidence concerns the gene LGR4 and varicose ulcer.