Mu et al. observed a significant down-regulation of miR-10a expression in FLSs of RA patients as compared to osteoarthritis controls, leading to the activation of the NF-κB signaling pathway by up-regulating miR-10a target genes—interleukin-1 receptor-associated kinase 4 (IRAK4), transforming growth factor beta (TGF-β)-activated kinase 1 (TAK1). The gene discussed is IRAK4; the disease is osteoarthritis.