Although the effect of modulating TRPM2 channels must be carefully verified because of conflicting views of TRPM2 (Ca2+ influx through TRPM2 induces apoptosis through goldnano-conjugated doxorubicin) [133], enhanced PyK2 phosphorylation through Ca2+ signaling presents further challenges in verifying the precise mechanism for cancer therapy. This evidence concerns the gene PTK2B and cancer.