ADP-ribosylation factor-GTPase activating protein (Arf-GAP), with an SH3 domain, ankyrin repeat, and PH domain-containing protein 1 (ASAP1, also called DDEF1 or AMAP1), is highly expressed on breast cancer cells and mediates breast cancer invasion and metastasis [106]. The gene discussed is ASAP1; the disease is breast carcinoma.