Additionally, the inhibition of SOCE by the SOCE inhibitors shOrai1 and SKF96365 increased PyK2 dephosphorylation and focal adhesion in mouse glioma cells (C6), human glioma cells (U251 and SNB19), and human melanoma cells (WM793) [129,130,131]. The gene discussed is PTK2B; the disease is glioma.