CCR7, which binds with CCL19, stimulated the phosphorylation of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in head and neck squamous cell carcinoma cell lines (PCI-4B and PCI-37B) [108]. The gene discussed is STAT3; the disease is head and neck squamous cell carcinoma.