Our analysis of the AD interactome indicates that 14-3-3G interacts directly with tau (TAU) and other aggregate proteins, including ankyrin-3 (ANK3), plectin (PLEC), kinesin heavy chain 5C (KIF5C), and hexokinase (HXK1) (Figure 1b,c)—all of which play key roles in neurodegenerative-disease aggregation. Here, PLEC is linked to neurodegenerative disease.