We next assessed the impact of RNAi-mediated knockdowns targeting the closest C. elegans orthologs of the above proteins in two nematode models of neurodegenerative aggregation: strain AM141, expressing a polyglutamine-array marker (Q40::YFP) in muscle cells as a model of huntingtin-like aggregation in Huntington’s disease (HD) neurons; and CL2355, which forms AD-like amyloid deposits in neurons expressing human Aβ1–42. Here, HTT is linked to juvenile Huntington disease.