Analyzing the predictive potential of the MIF expression at baseline for the change in depression severity, we found a positive correlation for the HAM-D (rho = 0.212, p = 0.021) and the MADRS (rho = 0.241, p = 0.008) absolute change in the total but not in the sex-separated cohort, i.e., high initial MIF gene expression levels predicted less improvement. This evidence concerns the gene MIF and major depressive disorder.