Compared with EcobNPV-QV, immune-related gene modular serine protease (Gene ID: Eg_24_090_0), peptidoglycan recognition protein 4 (Gene ID: Eg_16_351_1), suppressor of cytokine signaling 2 (Gene ID: Eg_17_178_1) and CWF19-like protein 2 homologs (Gene ID: Eg_18_286_1) were up-regulated after EcobNPV-QF4 infection in E. grisescens. The gene discussed is CWF19L2; the disease is infection.