Serum TNF-α was 94.4% higher and IL-6 32.6% higher in the AD model than in controls (p < 0.001), but values were reduced as follows: 1 mg/kg 5-MTHF: TNF-α by 22.7%, IL-6 to 80.5%; 5 mg/kg 5-MTHF: TNF-α by 25.6%, IL-6 to 85.7%; 10 mg/kg 5-MTHF: TNF-α by 24.6%, IL-6 to 73.6%; donepezil: TNF-α by 22.9%, IL-6 to 81.3% (p < 0.05 for TNF-α, Figure 4e; p < 0.01 for IL-6, Figure 4f). This evidence concerns the gene IL6 and Alzheimer disease.