Treatment with 1 mg/kg 5-MTHF increased SOD by 23.5%, with 5 mg/kg 5-MTHF by 23.0%, with 10 mg/kg 5-MTHF by 30.1% and with donepezil by 36.0% compared with untreated AD rats (p < 0.05, Figure 4a). Here, SOD1 is linked to Alzheimer disease.