Serum levels of EGF, G-CSF, GM-CSF, IL-1ra, IL-1α, IL-1β, IL-2, IL-4, IL-7, IL-8, EOTAXIN, fractalkine, GRO, P-10, MDC, MIP-1α, MIP-1β, IFNα2, and sCD40L were significantly lower in female COVID-19 patients compared to controls. This evidence concerns the gene IL1B and COVID-19.