In male participants, EGF, GM-CSF, IL-1ra, IL-1α, IL-1β, IL-2, IL-4, IL-7, IL-15, EOTAXIN, MDC, MIP-1α, MIP-1β, IFNα2, and sCD40L were significantly lower in COVID-19 patients compared to controls. The gene discussed is CD40LG; the disease is COVID-19.