Remarkably, our results showed decreased serum levels of TNFα, IL-4, IL-2, IL-1β, IL-2, IL-7, and GM-CSF in COVID-19 patients compared to controls, which indicates that the cytokine profile in mild cases of COVID-19 does not match a classical cytokine storm where TNFα is considered the leading cytokine and a therapeutic target. This evidence concerns the gene IL1B and COVID-19.