Bexarotene (Targretin, LGD1069), a synthetic retinoid, has demonstrated significant inhibition of the metastasis and angiogenesis of NSCLC cells by suppressing vascular endothelial growth factor (VEGF) and metalloproteinase (MMP) expression through downregulation of the α7nAChR-mediated c-JUN NH2-terminal kinase/extracellular signal-regulated kinase (JNK/ERK) signaling pathway [71]. The gene discussed is CHRNA7; the disease is non-small cell lung carcinoma.