Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations, epidermal growth factor receptor (EGFR) mutations, ROS Proto-Oncogene 1, Receptor Tyrosine Kinase (ROS1) and echinoderm microtubule–associate protein such as 4/anaplastic lymphoma kinase (EML4-ALK) fusion are the most gene mutations distinct in non-smokers, for which treatment strategies with medications to these mutations improved survival in ADC [16,17,18,19]. The gene discussed is KRAS; the disease is AIDS dementia complex.