X-Linked hypophosphatemia (XLH; Online Mendelian Inheritance in Man (OMIM) #307800) is a rare, genetic and progressive musculoskeletal disease caused by mutations that lead to loss of function of the X-linked homologous endopeptidase (PHEX) gene (OMIM: #300550) that regulates phosphate [1]. This evidence concerns the gene PHEX and X-linked hypophosphatemia.