GRAMD1B and myeloid sarcoma: In contrast, in active MS lesions, expression of GRAMD1B on vessel-associated astrocytes was markedly decreased irrespective of the distance from blood vessels, while in inactive MS lesions, we observed a diffuse increase in staining of GFAP (sign of astrocytosis) accompanied by diffuse, higher GRAMD1B expression on astrocytes irrespective of the distance from blood vessels (Figure 6Q; MS active plaque and MS inactive plaque).