Regarding the brain tissue, it is worth mentioning that a stop variant in GRAMD1B (p.Arg128*) was identified in a consanguineous family affected by autosomal recessive intellectual disability (ARID), and in silico GRAMD1B expression was reported in developing and adult brain tissue, mostly in white matter, cerebellum and basal nuclei [54]. Here, GRAMD1B is linked to intellectual disability, autosomal recessive.