IGHE and autoimmune disease: Very little is known about the function of the gene in the context of autoimmune disease, although a potential role in the immune system has been inferred by the identification of a SNP (rs7939777, 42.3 kb apart from p.S601P variant) in the GRAMD1B region having an eQTL effect on the serological levels of immunoglobulin E (IgE) in asthmatic patients.