Furthermore, it is interesting to note the deficiency of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3), which we observed in both syndromes and which has recently been identified as a novel protein-modulating neuroinflammation, thereby increasing the risk of neurodegeneration and Alzheimer’s disease [54]. This evidence concerns the gene IFITM3 and early-onset autosomal dominant Alzheimer disease.