SETX and aceruloplasminemia: Dominant mutations in SETX cause juvenile-onset amyotrophic lateral sclerosis type 4 (ALS4), while recessive mutations are associated with ataxia-oculomotor apraxia 2 (AOA2) characterized by cerebellar ataxia, oculomotor apraxia, and axonal sensorimotor neuropathy [57,59].