In addition, interactions between the COL11A1 rs3753841 T, COL11A1 rs1676486 C, COL11A2 rs1799907 T and/or COL5A1 rs7174644 AGGG alleles, the latter of which is also located within the functional COL5A1 3′-UTR, were previously reported to be associated with increased risk of Achilles tendinopathy in two populations [16] and carpal tunnel syndrome [17]. This evidence concerns the gene COL5A1 and carpal tunnel syndrome.