GPT and hepatocellular carcinoma: The features of the liver were consistent with this fact, wherein the LA-PAMAM-pmiR-181c-5p treated group showed an increased number of HCC nodules, severe malignant histological changes, and upregulation in liver function enzymes (ALT and AST) in the serum, in correspondence with the malignant features shown by T. Uehara et al., 2014 [56], which were evident in 100% of all mice compared to the LA-PAMAM-pNull group, indicating that miR-181c-5p might be correlated with the progression of HCC.