The current analysis showed the proposed impact of miR-181c-5p to act as oncomiR and to control many significantly enriched pathways and biological processes related to HCC, such as immune system and metabolic pathways, cellular response to cytokine stimulus, cytokine–cytokine receptor interaction, and the intestinal immune network for IgA production, as well as tryptophan metabolism, retinol metabolism, arginine and proline metabolism, chemical carcinogenesis, and parathyroid hormone synthesis, secretion, and action. Here, PTH is linked to hepatocellular carcinoma.