The twenty miR-181c-5p targets significantly predicted in this study, “PLAC8, KBTBD11, CXCL12, FOS, MME, FBXL3, KMO, EGR1, DCN, BCHE, LIFR, CYP26A1, HSD11B1, CYP2C8, TMEM27, ITLN1, GPM6A, CNDP1, GYS2, and INMT” were downregulated in HCC [52]. This evidence concerns the gene EGR1 and hepatocellular carcinoma.