In addition, these genes were enriched in the pathways of “cell cycle”, “cellular senescence”, “microRNAs in cancer”, “bladder cancer”, “cocaine addiction”, “non-small cell lung cancer”, “melanoma”, “inositol phosphate metabolism”, “glioma”, “pancreatic cancer” and “chronic myeloid leukemia”, and the potential relationship of miRNA regulating these pathways via target genes (including CDC25A, CDK5R1, E2F3 and SYNJ1) was displayed in the Sankey diagram (Figure 6B). The gene discussed is E2F3; the disease is melanoma.