According to the National Comprehensive Cancer Network (NCCN) Guidelines: Genetic/Familial High-Risk Assessment: Colorectal, version 1.2022, the estimated lifetime risk of gastric cancer in patients with an inherited APC mutation is 0.1–7.1% compared with 0.8% in the general population, and the average onset is between 52 and 57 years. The gene discussed is APC; the disease is gastric cancer.