One example of an mt-ARS being associated with a unique clinical phenotype is mitochondrial tyrosyl-tRNA synthetase (YARS2), which is the only mt-ARS associated with a syndrome characterized by myopathy, lactic acidosis, and sideroblastic anemia (MLASA), which can variably occur along with pancreatic insufficiency [64,74]. The gene discussed is YARS2; the disease is myopathy.