IARS2 and cataract-growth hormone deficiency-sensory neuropathy-sensorineural hearing loss-skeletal dysplasia syndrome: Another example of highly specific phenotypes associated with mt-ARSs is mitochondrial isoleucyl-tRNA synthetase (IARS2), which is associated with a condition characterized by cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia (CAGSSS) [37].