SARS2 and hyperuricemia-pulmonary hypertension-renal failure-alkalosis syndrome: It is possible that this non-canonical role of SARS2, for example, contributes to the uniqueness of the HUPRA syndrome phenotype; given that HUPRA syndrome has only been associated with SARS2, it is possible that a loss of SARS2 function is not only leading to defects in mitochondrial translation due to a lack of charged tRNASer but is also due to a lack of m3C32 on both mt-tRNASer (UCN) and mt-tRNAThr.