SMAD2 and neoplasm: Functionally, the 15 EMT-related genes (MMP3, ITGAV, KRT14, PLEK2, SNAI2, GSK3B, ITGB1, MAP1B, TCF3, VPSA13, SMAD2, MMP2, SPARC, WNT5A, and ITGA5) were involved in several biological pathways associated with cellular proliferation, extracellular matrix degradation, regulation of cell apoptosis, mutation burden with the involvement of chromatin remodeling genes, mitosis rate, and tumor cell invasion, leading to modification in final cellular phenotype.