In total, 8 patients (~53%), amid the remaining 15, harbored a CNV that encompassed, total or partially, at least one known microcephaly gene (ADNP, CACNA1G, DONSON, GRIN2A, ITSN1, MCPH1, RPL11, TBCD, and TRAPPC9), for which the reported mechanism for microcephaly is mostly LoF. This evidence concerns the gene ITSN1 and microcephaly.