IRF1 and acute myeloid leukemia: More specifically, the expression of 19 genes (CHMP4C, CYCS, NLRP2, GSDME, CASP9, PLCG1, IL1A, TP63, CHMP2A, PRKACA, HMGB1, BAX, GSDMB, CHMP4A, GPX4, CHMP4B, CHMP7, NLRP1, CASP6) were downregulated while the expression of 28 other genes (CASP3, GSDMA, AIM2, NLRP6, CHMP3, IRF2, TIRAP, SCAF11, PJVK, CASP8, GSDMC, IL6, PYCARD, IL18, GSDMD, NLRC4, IRF1, TP53, TNF, NOD2, CASP5, CASP4, GZMB, CASP1, NLRP3, IL1B, GZMA, ELANE) were upregulated in AML compared with normal samples.