It was found that a high expression of GSDMB was associated with a low survival rate and a high metastasis rate in breast cancer [16,17], and a high level of GSDMD in lung adenocarcinoma was associated with a poor prognosis, while GSDMD can inhibit tumor proliferation and was related with favorable prognosis in non-small cell lung cancer [18]. The gene discussed is GSDMB; the disease is lung adenocarcinoma.