In this study, we found that the pyroptosis genes including GSDMB, GSDME, NLRC4, NLRP2 and GZMA were hazardous genes in AML, and the genes of proinflammatory cytokines such as IL6 and TNF were found to be protective genes which maybe related with tumor microenvironment. This evidence concerns the gene GSDMB and acute myeloid leukemia.