In this study, we found that most of the pyroptosis-related genes were differentially expressed in AML and normal controls, and the level of the membrane repair genes such as CHMP2A, CHMP4A, CHMP4B, CHMP4C, CHMP7, were downregulated while the level of canonical and non-canonical pyroptosis genes such as GSDMD, NLRP3, NLRC4, AIM2, GSDMA, GSDMB, GSDMC, GSDME, GZMB, IL18 and IL1B were upregulated in AML compared with normal samples. Here, CHMP4B is linked to acute myeloid leukemia.