TP53 and gastric cancer: In addition, the differences in the expression levels of genes (encoding hub proteins, reporter TFs, or reporter receptors) between the risk groups showed that up-regulation of the expression of PDGFRB, AR, and SKIL was associated with a higher risk of GC, while down-regulation of the expression of TP53, TRIM29, HOXA11, NELFB, and GRK6 was associated with a higher risk of GC (Figure 5).