P/LP gene variants were detected in 23.9% (23 cases), among which 8 were recurrent hydrops (2 cases with GUSB and 6 with 1 of GBA, LZTR1, FOXC2, FOXP3, GBE1, or RAPSN); 15 were non-recurrent NIHF (4 cases with PTPN11 gene, 11 with 1 of MAP2K2, ALG12, CDAN1, LZTR1, ANKRD11, KRAS, NRAS, EPHB4, PIK3CA, NEB, or GUSB). The gene discussed is MAP2K2; the disease is edema.