CCR5 and HIV infectious disease: PLGA nanoparticles, loaded with triplex-forming peptide nucleic acids (PNAs) and single-stranded donor DNA molecules introducing site-specific repair and recombination, were used to specifically modify either the CCR5 gene or the β- or γ-globin gene in relevant mouse models in order to prevent HIV infection or correct the βIVS2-654 mutation, respectively [217,218].