In this screening of 148 patients predisposed to BC, with no deleterious variants in BRCA1/2, we detected a deleterious large germline rearrangement in the CDH1 gene: c.164−5939_387+812del (Figure 2A,B), leading to the loss of the exon 3 and the production of a truncated protein (p.Val55GlyfsX38) as well as two large rearrangements in intron 2 (deletion and duplication) (Figure 3 and Figure 4). The gene discussed is BRCA1; the disease is breast cancer.