The proteoglycans in cancer pathway (ecb05205) regulates proteoglycans in the extracellular matrix, which influences the behavior of cancer cells and their microenvironment by interacting with various cytokines (e.g., TWIST2), growth factors (e.g., HGF) and cell surface receptors (e.g., EGFR) [90]. This evidence concerns the gene EGFR and cancer.