The proteoglycans in cancer pathway (ecb05205) regulates proteoglycans in the extracellular matrix, which influences the behavior of cancer cells and their microenvironment by interacting with various cytokines (e.g., TWIST2), growth factors (e.g., HGF) and cell surface receptors (e.g., EGFR) [90]. The gene discussed is TWIST2; the disease is cancer.