FAP and adenoma: Due to its high penetrance and the ability to monitor adenoma development via endoscopy, FAP has long been studied as a prototype model for CRC development and as an illness suited for chemoprevention interventions [10,11], as successful chemoprevention may enable the delay of surgery, thus shortening the periods with surgery-related complications and delaying post-surgical adenoma progression, so the risks of malignancy and further operations are decreased.