Furthermore, high pretreatment levels of BIM RNA strongly induced the apoptosis of EGFR-mutated, HER2-amplified, and PI3CA-mutated cancer cells when subjected to EGFR, HER2, and PI3K inhibitor treatment, respectively; however, there was no association of the BIM pretreatment level with the responsiveness to cytotoxic chemotherapeutic agents, such as Taxol, gemcitabine, and cisplatin [69]. This evidence concerns the gene BCL2L11 and cancer.