EGFR and non-small cell lung carcinoma: Using small hairpin RNAs (shRNAs), the attenuation of RBM10 expression led to diminished EGFR-TKI-induced apoptosis by decreasing the ratio of BCL-XS (pro-apoptotic isoform) to BCL-XL (anti-apoptotic isoform), resulting in increased BCL-XL expression relative to BCL-XS expression in the EGFR-mutated NSCLC cell lines PC-9 and H3255.