The combination of all proteins showed increased accuracy (AUC = 0.889), compared to PSA alone (AUC = 0.841), with 85.29% of total correct classification and 91.43% and 78.79% correct classification of PCa GS ≤ 7 and PCa GS ≥ 8 groups, respectively. Here, KLK3 is linked to posterior cortical atrophy.