SLC5A5 and thyroid gland carcinoma: An in vitro study by Anschlag et al. showed that technetium-99 m uptake (as a surrogate for NIS expression) was increased with a maximum of 326% in a well-differentiated human papillary thyroid carcinoma cell line after exposure to lenvatinib, but smaller effects were observed in poorly differentiated thyroid carcinoma cell lines [25].