Based on the luminal or abluminal lining and placement of CD31+ endothelial and/or P-gp+/mitochondria+/S100A10+ tumor cells nucleus, blood vessels were identified and divided into two groups corresponding to co-opted vessels (formed by vascular co-option) or sprouted vessels (created by sprouting angiogenesis) (Figure 11). The gene discussed is PECAM1; the disease is neoplasm.