For IDH-mutant astrocytoma, the results revealed an increased P-gp expression by tumor cells in the peritumoral and intratumoral areas compared with normal one, a progressively increased mitochondria expression by tumor cells from normal to the intratumoral area, and no significant data concerning CD31 and P-gp + CD31 by ECs in all three areas. The gene discussed is IDH2; the disease is neoplasm.