Overall, these morphological and morphometric evaluations in IDH-WT glioblastoma revealed an increased P-gp, mitochondria, and S100A10 expression by tumor cells during vascular co-option and an increased CD31, P-gp + CD31, and mitochondria + CD31 expression by ECs during sprouting angiogenesis, and additionally, 93.33% of IDH-WT glioblastoma showed vascular co-option in the peritumoral area, while 100% of the same showed sprouting angiogenesis in the intratumoral area. The gene discussed is IDH2; the disease is glioblastoma.