Of interest, genes supporting the inflammation and fibrogenesis in IPF, such as TGF-β1, interleukin-1 receptor alpha (IL1RN), interleukin 8 (IL-8), Toll-like receptor 3 (TLR3), telomerases, tumor protein 53 (TP53), are also associated with cancer and genome-wide methylation studies, as well as gene expression studies, showed several parallelisms between the pathogenetic mechanisms that drive IPF and lung cancers. This evidence concerns the gene TGFB1 and lung cancer.