Polymorphisms of SFTPA1 and SFTPA2, indeed, predispose to IPF through ER stress and consequent alterations in APC type 2, whilst pathogenetic variants of SFTPA2 are responsible for ILD2, an autosomal dominant condition characterized by a strong genetic predisposition to lung cancer. This evidence concerns the gene SFTPA2 and idiopathic pulmonary fibrosis.