The second hypothesis proposed by Binstadt et al. [16] is the “cytokine plasticity hypothesis”, where the biological activity of IL-1 and IL-6 blockers could lead to a favorable condition for adverse reactions similar to drug-induced hypersensitivity syndrome (DIHS) and sJIA-LD in predisposed children [16]. The gene discussed is IL6; the disease is systemic-onset juvenile idiopathic arthritis.