In addition, recent studies have demonstrated the role of ECM1 in the genetic predisposition to the inflammatory bowel disease (IBD) ulcerative colitis [34,35], the acquisition of immune tolerance and allergic responses via particular T-cell subsets such as CD4+CD25+ regulatory T cells and Th2 cells [31,36], and activation of abundant B-cell biology [33]. This evidence concerns the gene ECM1 and inflammatory bowel disease.