The mouse skin sites injected either with a rabbit anti-ECM1 polyclonal antibody or an affinity-purified IgG from LS sera exhibited a clinicopathology compatible with the early clinical stage of LS, including erythematous swelling (dermal inflammation) and dilated blood vessels (telangiectasia) for up to two weeks after the initial injection. Here, ECM1 is linked to Telangiectasia.