More critically, the skin pathology of LS shares considerable overlap with that of LiP (OMIM 247100), an ECM1-deficient genetic skin disease [28], for example, trauma-induced inflammation (also known as Koebner’s phenomenon) and lesional skin microscopy showing the atrophic epidermis with hyperkeratosis, disruption and duplication of the basement membrane, and hyaline (glassy-like) collagen changes and telangiectasia in the upper dermis (Figure 3). The gene discussed is ECM1; the disease is Leigh syndrome.