However, nesfatin-1 expression was significantly associated with high-grade RCC (OR = 0.29, 95% CI = 0.13–0.61, p = 0.001) (Figure 2D) and significantly correlated with poorer OS in RCC (HR = 3.86, 95% Cl = 2.18–6.85; p < 0.01) (Figure 2E). This evidence concerns the gene NUCB2 and renal cell carcinoma.