Secondly, according to the new WHO CNS5 scheme, gliomas with IDH-wildtype and grade 2–3 histopathological types should have one of the following characteristics in order to be diagnosed as glioblastomas: high levels of epidermal growth factor receptor (EGFR), whole chromosome 7 gain and whole chromosome 10 loss (+7/−10), or mutations in the TERT promoter. This evidence concerns the gene TERT and central nervous system cancer.