In a recent prospective observational study, the largest single institution series including 27 non BRCA gene mutation carriers, Rush et al. [40] reported a diagnosis of STIC in a carrier of a PALB2 mutation with a strong family history of both BC and EOC; another case report by Gregory-Davis et al. [45] reported a diagnosis of STIC in a RAD51D mutation carrier; HGSC and a low grade serous carcinoma were reported by Schoolmeester et al. [46] in two patients, carrying mutations in RAD51C and CHEK 2, respectively. This evidence concerns the gene RAD51C and breast cancer.