The “age factor” is probably one of the main contributors for the higher incidence of occult carcinoma with respect to the general population: the median age of our high-risk population was 49 (range 27–79), much higher than the age recommended by international guidelines for RRS (before 40 for BRCA1, and before 45 for BRCA2) [21,42]. This evidence concerns the gene BRCA1 and carcinoma.