In summary, p53, known as a tumor suppressor gene, becomes an oncogene, a mutant variant that, by a gain of function (GOF), alters the secretion of enzymes implicated in the modulation of extracellular matrix components mediates crosstalk between tumor cells and the microenvironment, acidifies the tumor microenvironment, and alters inflammatory cytokine secretion [13,14]. The gene discussed is TP53; the disease is neoplasm.