Analyzing the clinical phenotype of TP53 mutations in radiotherapy patients for rhabdomyosarcoma and Ewing’s sarcoma in a patients lot including 397 cases, most Ewing’s sarcomas, the study by Casey et al. demonstrated a reduced tumor control in the case of any types of sarcomas for both TP53 mutant cases and p53 pathway alteration. The gene discussed is TP53; the disease is neoplasm.