TP53 mutation, HIF-1, TKTL, GLUT-1, LDH-A, HKII and MCTs were identified as modulating factors of the Warburg effect and of radioresistance and chemoresistance in HNSCC [70,71,72,73,74,75,76,77,78]. This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.