Evidence is accumulating to suggest that FUT3 polymorphisms or Le phenotypes are associated with a variety of pathologic conditions, including Helicobacter pylori infection, ischemic heart diseases, intestinal infections, inflammatory bowel diseases, ankylosing spondylitis, COVID-19 susceptibility, and autoimmune neutropenia [20,21,22,23,24,25]. Here, FUT3 is linked to digestive system infectious disorder.