ARMC5 germline mutations are responsible for up to 50% (near to 80% in Japanese) of familial or sporadic PMAH and lead to larger adrenal hyperplasia, higher hypercortisolism, a higher number of nodules, hypertension, higher fasting glucose, and HbA1c [4,6]. The gene discussed is ARMC5; the disease is congenital adrenal hyperplasia.