Dysregulation of noncanonical NF-κB activation affects various immune cells to different extents, such as (i) causing aberrant survival of self-reactive B cells, rendering them resistant to negative selection and leading to autoimmune antibody production associated with a number of autoimmune diseases, and (ii) resulting in aberrant chemokine production and inflammatory-cell recruitment in endothelial cells, T cells, and monocytes by diverse mechanisms [55]. This evidence concerns the gene NFKB1 and autoimmune disease.