EZH2 and systemic lupus erythematosus: In Chr 4: 105146116-154, where there is hypermethylation of CpG sites, there is also a binding site for the repressive transcription factor, enhancer of zeste homolog 2 (EZH2), which might play a key role in the T-cell epigenetic conformational changes that are associated with disease flare in lupus [51].