The correlation analysis of TET2 methylation and global methylation or hydroxymethylation failed to show a positive correlation, which implies that the 5-mc/5-hmc dynamics was not as straightforward as depicted in the chemical equation and that the role of TET2 methylation in the pathogenesis of SLE disease development must be far more complicated and yet to be fully elucidated. The gene discussed is TET2; the disease is systemic lupus erythematosus.